1,177 research outputs found
L-Arginine promotes gut hormone release and reduces food intake in rodents
Aims: To investigate the anorectic effect of Lâarginine (LâArg) in rodents.
Methods: We investigated the effects of LâArg on food intake, and the role of the anorectic gut hormones glucagonâlike peptideâ1 (GLPâ1) and peptide YY (PYY), the Gâproteinâcoupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents.
Results: Oral gavage of LâArg reduced food intake in rodents, and chronically reduced cumulative food intake in dietâinduced obese mice. Lack of the GPRC6A in mice and subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. LâArg stimulated GLPâ1 and PYY release in vitro and in vivo. Pharmacological blockade of GLPâ1 and PYY receptors did not influence the anorectic effect of LâArg. LâArgâmediated PYY release modulated net ion transport across the gut mucosa. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of LâArg suppressed food intake in rats.
Conclusions: LâArg reduced food intake and stimulated gut hormone release in rodents. The anorectic effect of LâArg is unlikely to be mediated by GLPâ1 and PYY, does not require GPRC6A signalling and is not mediated via the vagus. I.c.v. and i.p. administration of LâArg suppressed food intake in rats, suggesting that LâArg may act on the brain to influence food intake. Further work is required to determine the mechanisms by which LâArg suppresses food intake and its utility in the treatment of obesity
Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier
HIV-1 circulates both as free virus and within immune cells, with the level of free virus being predictive of clinical course. Both forms of HIV-1 cross the blood-brain barrier (BBB) and much progress has been made in understanding the mechanisms by which infected immune cells cross the blood-brain barrier BBB. How HIV-1 as free virus crosses the BBB is less clear as brain endothelial cells are CD4 and galactosylceramide negative. Here, we found that HIV-1 can use the mannose-6 phosphate receptor (M6PR) to cross the BBB. Brain perfusion studies showed that HIV-1 crossed the BBB of all brain regions consistent with the uniform distribution of M6PR. Ultrastructural studies showed HIV-1 crossed by a transcytotic pathway consistent with transport by M6PR. An in vitro model of the BBB was used to show that transport of HIV-1 was inhibited by mannose, mannan, and mannose-6 phosphate and that enzymatic removal of high mannose oligosaccharide residues from HIV-1 reduced transport. Wheatgerm agglutinin and protamine sulfate, substances known to greatly increase transcytosis of HIV-1 across the BBB in vivo, were shown to be active in the in vitro model and to act through a mannose-dependent mechanism. Transport was also cAMP and calcium-dependent, the latter suggesting that the cation-dependent member of the M6PR family mediates HIV-1 transport across the BBB. We conclude that M6PR is an important receptor used by HIV-1 to cross the BBB
Recognizing Members of the Tournament Equilibrium Set is NP-hard
A recurring theme in the mathematical social sciences is how to select the
"most desirable" elements given a binary dominance relation on a set of
alternatives. Schwartz's tournament equilibrium set (TEQ) ranks among the most
intriguing, but also among the most enigmatic, tournament solutions that have
been proposed so far in this context. Due to its unwieldy recursive definition,
little is known about TEQ. In particular, its monotonicity remains an open
problem up to date. Yet, if TEQ were to satisfy monotonicity, it would be a
very attractive tournament solution concept refining both the Banks set and
Dutta's minimal covering set. We show that the problem of deciding whether a
given alternative is contained in TEQ is NP-hard.Comment: 9 pages, 3 figure
General Gauge Mediation with Gauge Messengers
We generalize the General Gauge Mediation formalism to allow for the
possibility of gauge messengers. Gauge messengers occur when charged matter
fields of the susy-breaking sector have non-zero F-terms, which leads to
tree-level, susy-breaking mass splittings in the gauge fields. A classic
example is that SU(5) / SU(3) x SU(2) x U(1) gauge fields could be gauge
messengers. We give a completely general, model independent, current-algebra
based analysis of gauge messenger mediation of susy-breaking to the visible
sector. Characteristic aspects of gauge messengers include enhanced
contributions to gaugino masses, (tachyonic) sfermion mass-squareds generated
already at one loop, and also at two loops, and significant one-loop A-terms,
already at the messenger scale.Comment: 79 pages, 5 figure
The Regge Limit for Green Functions in Conformal Field Theory
We define a Regge limit for off-shell Green functions in quantum field
theory, and study it in the particular case of conformal field theories (CFT).
Our limit differs from that defined in arXiv:0801.3002, the latter being only a
particular corner of the Regge regime. By studying the limit for free CFTs, we
are able to reproduce the Low-Nussinov, BFKL approach to the pomeron at weak
coupling. The dominance of Feynman graphs where only two high momentum lines
are exchanged in the t-channel, follows simply from the free field analysis. We
can then define the BFKL kernel in terms of the two point function of a simple
light-like bilocal operator. We also include a brief discussion of the gravity
dual predictions for the Regge limit at strong coupling.Comment: 23 pages 2 figures, v2: Clarification of relation of the Regge limit
defined here and previous work in CFT. Clarification of causal orderings in
the limit. References adde
The basic approval voting game
We survey results about Approval Voting obtained within the standard framework of game theory. Restricting the set of strategies to undominated and sincere ballots does not help to predict Approval Voting outcomes, which is also the case under strategic equilibrium concepts such as Nash equilibrium and its usual refinements. Strong Nash equilibrium in general does not exist but predicts the election of a Condorcet winner when one exists
Additive manufacturing electrochemistry: An overview of producing bespoke conductive additive manufacturing filaments
Additive manufacturing represents a state-of-the-art technology that has been extensively disseminated in both the academic and industrial sectors. This technology enables the cost-effective, simple, and automated production of objects with diverse designs. Moreover, within the academic community, additive manufacturing has provided genuine scientific revolutions, particularly in the field of electrochemistry, due to the accessibility of the Fused Filament Fabrication printing methodology, which utilizes thermoplastic filaments for electrochemical platforms. Additive manufacturing has facilitated the production of conductive components for various applications, including electrochemical sensors, batteries, supercapacitors, and electrical circuits. Within recent years, the scientific community has taken an interest in bespoke filaments that are doped with highly conductive particles, which can be optimized and tailored enabling groups to produce a wide range of filaments with uncountable applications. Thus, the present review article explores the distinct methods of bespoke filament manufacturing, emphasizing its significance in the scientific landscape, and investigating the principal materials utilised in its production, such as thermoplastics, plasticizers, and conductive substances, focusing on electrochemistry applications. Furthermore, all reported additive manufacturing methods will be thoroughly discussed, along with their main advantages and disadvantages. Last, future perspectives will be addressed to guide novel advancements and applications of bespoke filaments for use within electrochemistry
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